Andrea Bistrović Popov

Andrea Bistrović Popov

Post Doctoral Researcher

Andrea obtained her PhD in organic medicinal chemistry from the Faculty of Chemical Engineering and Technology at the University of Zagreb. During her PhD she was involved in the synthesis of novel purine isosteres as anticancer agents using eco-friendly synthetic approaches and was awarded with the L’Oréal-UNESCO fellowship “For Women in Science”. She joined the Fruk group in 2018 to work on the design of new nanovehicles as smart drug-delivery systems for the treatment of pancreatic cancer funded by the EPSRC IRC Targeted delivery for hard-to-treat cancer. She is a College Research Associates at Kings College, Cambridge and outside the lab, she likes to travel and explore new cultures.

Selected Publications

1. A. Bistrović Popov, F. Melle, E. Linnane, C. Gonzalez Lopez, I. Ahmed, B. Parshad, C. O. Franck, H. Rahmouned, F. Richards, D. Munoz-Espin, D. Jodrelle, D. Fairen-Jimenez, L. Fruk, Size-tuneable and immunocompatible polymer nanocarriers for drug delivery in pancreatic cancer, Nanoscale, 2022, 14, 6656.

2. L. B. Crocker, J. H. Lee, S. Mital, G. C. Mills, S. Schack, A. Bistrović Popov, C. O. Franck, I. Mela, C. F. Kaminski, G. Christie, L. Fruk, Tuning Riboflavin Derivatives for Photodynamic Inactivation of Pathogens, Sci. Reports. 2022, 12, 1.

3. A. Bistrović Popov, R. Vianelo, P. Grbčić, M. Sedić, S. K. Pavelić, K. Pavelić, S. Raić-Malić, S. Novel Bis- and Mono-Pyrrolo[2,3-d]pyrimidine and Purine Derivatives: Synthesis, Computational Analysis and Antiproliferative Evaluation. Molecules 2021,26, 3334.

4. C. O. Franck, L. Franslau, A. Bistrović Popov, P. Tyagi, L. Fruk, Biopolymer-based Carriers for DNA Vaccine Design, Angew. Chem. 2020, 60, 63, 13225.

5. A. Bistrović Popov, L. Krstulović, M. C. Taylor, J. M. Kelly, S. Raić-Malić, Design, synthesis, antitrypanosomal activity, DNA/RNA binding and in vitro ADME profiling of novel imidazoline-substituted 2-arylbenzimidazoles, Eur J Med Chem. 2020, 173, 63.

6. A. Bistrović Popov, I. Stolić, L. Krstulović, M. C. Taylor, J. M. Kelly, S. Tomić, L. Tumir, M. Bajić, S. Raić-Malić, Novel symmetric bis-benzimidazoles: Synthesis, DNA/RNA binding and antitrypanosomal activity, Eur J Med Chem. 2019, 173, 63.

7. A. Bistrović, L. Krstulović, I. Stolić, D. Drenjančević, J. Talapko, M. C. Taylor, J. M. Kelly, M. Bajić, S. Raić-Malić, Synthesis, anti-bacterial and anti-protozoal activities of amidinobenzimidazole derivatives and their interactions with DNA and RNA, J Enyzme Inhib Med Chem. 2018, 33, 1323.

8. A. Bistrović, P. Grbčić, A. Harej, M. Sedić, S. Kraljević-Pavelić, S. Koštrun, J. Plavec, D. Makuc, S. Raić-Malić, Small molecule purine and pseudopurine derivatives: synthesis, cytostatic evaluations and investigation of growth inhibitory effect in non-small cell lung cancer A549, J Enyzme Inhib Med Chem. 2018, 33, 271.

9. A. Bistrović, L. Krstulović, A. Harej, P. Grbčić, M. Sedić, S. Koštrun, S. Kraljević-Pavelić, M. Bajić, S. Raić-Malić, Design, synthesis and biological evaluation of novel benzimidazole amidines as potent multi-target inhibitors for the treatment of non-small cell lung cancer, Eur J Med Chem. 2018, 143, 1616.

10. A. Bistrović, A. Harej, P. Grbčić, M. Sedić, S. Kraljević Pavelić, M. Cetina, S. Raić-Malić, Synthesis and anti-proliferative effects of mono- and bis-purinomimetics targeting kinases, Int J Mol Sci. 2017, 18, 2292.

11. A. Bistrović, N. Stipaničev, T. Opačak-Bernardi, M. Jukić, S. Martinez, Lj. Glavaš-Obrovac and S. Raić-Malić, Synthesis of 4-aryl-1,2,3-triazolyl appended natural coumarin-related compounds with antiproliferative and radical scavenging activities and intracellular ROS production modification, New J Chem. 2017, 41, 7531.

12. S. Krištafor, A. Bistrović, J. Plavec, D. Makuc, T. Martinović, S. Kraljević Pavelić, S. Raić-Malić, One-pot click synthesis of 1,2,3-triazole embedded unsaturated uracil derivatives and hybrids of 1,5- and 2,5-disubstituted tetrazoles and pyrimidines, Tetrahedron Lett. 2015, 56, 1222.

13. T. Gazivoda Kraljevic, A. Bistrović, M. Dedic, S. Kraljevic Pavelic, M. Sedic, S. Raic-Malic, Efficient palladium-mediated or base-induced 5-endo-dig cyclisation of C5-alkynylated pyrimidine derivatives: conventional and microwave-assisted synthesis of novel furo [2, 3-d] pyrimidines, Tetrahedron Lett. 2012, 53, 5144.