We use hybrid material design and photochemistry to prepare new generation of drug nanocarriers, antimicrobial agents and diagnostic tools for detection of senescent (aged) cells.
Within a large collaborative project funded by UK Research Council we work towards drug nanocarriers for hard-to-treat cancers such as pancreatic and lung cancer, characterised by dense, heterogenous tumour tissue known as stroma. Our approach involves use of biopolymer carriers decorated with anti-stromal and targeting species for improved drug delivery.
We also explore therapeutic and diagnostic strategies for ageing (senescent) cells, particularly those aged as a result of the chemotherapeutic treatment (with our collaborator Daniel Munoz Espin), and use our nanostructured biopolymers to design a new generation of DNA vaccines (work done in collaboration with Astra Zeneca).
Recently, we teamed up with Hitachi to develop a photonic crystal based biosensing platform using tailored surface chemistry and high precision inkjet printing of DNAzymes and proteins, which could enable fast, label-free and sensitive detection of biomarkers.
Pancreatic cellular uptake of drug nanocarriers
Nanocarriers for pancreatic cancer cell targeting
Nanoscaffold for DNA vaccine design
Dr. Daniel Munoz Espin
Department of Oncology
University of Cambridge
Prof. Laura Ballerini
Scoula Internazionale Superiore di Studi Avanzati (SISSA)
And Univeristy of Trieste, Trieste, Italy