We have recently started employing our knowledge of hybrid materials and photochemistry to design nanostructured elements for drug delivery, diagnostics and drug formulation. Within a large collaborative project we design drug nanocarriers for hard-to-treat cancers such as pancreatic cancer, characterised by growth of dense tumor tissue surrounding cancer cells, which interferes with the successful delivery of the drugs. Together with our collaborator Daniel Munoz Espin (CRUK, Cambridge) we explore therapeutic and diagnostic strategies for ageing (senescent) cells, particulalry those aged by chemotherapy.
We use our hybrid biopolymers to prepare radionuclide carriers for lung cancer theranostic (in collaboration with Luigi Aloj.Department of Radiology,), to design a new generation of DNA vaccines (work done in collaboration with Astra Zeneca), and sunlight-triggered antiviral and antibacterial nanostructures
Gonzalez-Gualda, E., Paez-Ribes, M., Lozano-Torres, B., Macias, D., Wilson, J.R., Gonzalez-Lopez, C., Ou, H-L, Miron-Narroson, S., Zhang, Z., Lerida-Viso, A., blandez, J. F., Bernardos, A., Sancenon, F., Rovira, M., Fruk, L., Martinas, C. P, Serrano, M., Doherty G. J. , Martinez-Manez, R, Munoz-Espin, D. (2020). Galacto-conjugation of Navitoclax as an efficient strategy to increase senolytic specificity and reduce platelet toxicity, Aging Cell 19 (4), e13142.
*S.Šegota, D. Vojta, D. Kendziora, I. Ahmed, Lj. Fruk, G. Baranović, Ligand-dependent Nanoparticle Clustering within Lipid Membranes Induced by Surrounding Medium, J. Phys. Chem. B 2015, 119, 5208.
M. Ganau, A. Bosco, A. Palma, S. Corvaglia, P. Parisse, L. Fruk, A. P. Beltrami, D. Casselli, L. Casalis, G. Scoles, A DNA Based Immunoassay for the Label Free Detection of Glial Fibrillary Acid Protein in Multicell Lysates, Nanomedicine 2014, 11(2), 293
C. Cheng, I. Ahmed, Lj. Fruk, Reactive Oxygen Species Production by Catechol Stabilized Copper Nanoparticles, Nanoscale 2013, 11610.
B.Geiseler, M. Miljevic, P. Mueller, Lj. Fruk, Phototriggered Production of Reactive Oxygen Species by TiO2 Nanospheres and Rods, J. Nanomater. 2012,.
F. Bano, Lj. Fruk, B. Sanavio, M. Glettenberg, L. Casalis, C. M. Niemeyer, G. Scoles, Towards Multiprotein Nanochips Using Nanografting and DNA Directed Immobilization of Proteins, Nano Lett. 2009, 9(7), 2614.