BIO-CATALYSIS

We have been exploring the light-triggered chemical reactions for several years and developed mild, photo-activated strategies for nanoparticle functionalization as well as protein and DNA conjugation. This work led us to exploring light sensitive cofactors within enzymes to look for new ways to drive chemical reactions by irradiating them with visible light. We are currently focusing stable and biocompatible flavin derivatives that can be used as enantioselective catalysts. 

 

Selected Papers

  1. L. Crocker, P. Koehler, P. Bernhard, A. Kerbs, T. Euser, L.Fruk, Enzyme-inspired Flavin-polydopamine as a Biocompatible Nanoparticle Photocatalysts, Nanoscale Horiz. 2019, 4, 1318-1325.

  2. L. Crocker, L.Fruk, Flavin Conjugated Polydopamine Nanoparticles Displaying Light-Driven Monooxygenase Activity, Front. Chem. 2019, 

  3. S. I. Nehme, L. B. Crocker, Lj. Fruk, Flavin-Conjugated Iron Oxide Nanoparticles as Enzyme-Inspired Photocatalysts for Azo Dye Degradation, Catalysts 2020, 10(3), 324

  4. A. Kerbs, P. Mueller, M. Kaupp, I. Ahmed, A. S. Quick, D. Abt, M. Wegener, C. M. Niemeyer, C. Barner-Kowollik, Lj. Fruk, Photo‐Induced Click Chemistry for DNA Surface Structuring via Direct Laser Writing, Chemistry-A Eur. J. 2017, 21, 4990

  5. A. Vigovskaya, D.Abt, I. Ahmed, C. M. Niemeyer, C. Barner-Kowollik, Lj. Fruk, Photo Induced Chemistry for Design of Oligonucleotide Conjugates and Surfaces, J. Mater. Chem. B 2016, 4, 442.

  6. L. Stolzer, A. Vigovskaya, C. Barner-Kowollik, Lj. Fruk, A Self Reporting Tetrazole Based Linker for the Biofunctionalization of Gold Nanorods, Chemistry-A Eur. J. 2015, 21,14309

  7. L. Stolzer, A.S, Quick, D. Abt, A. Welle, D. Naumenko, M. Lazzarino, M. Wegener, C. Barner-Kowollik, L. Fruk, Photo Induced Surface Encoding of Gold Nanoparticles, Chem. Commun. 2015, 51, 3363.

  8. L. Stolzer, I. Ahmed, C. Rodriguez-Emmeneger, V. Trouilet, P. Bockstaller, C. Barner-Kowollik, L. Fruk, Light Induced Modification of Silver Nanoparticles with Functional Polymers, Chem. Commun. 2014, 50, 4430.

  9. M. Miljevic, B. Geiseler, T. Bergfeldt, P. Brockstaller, Lj. Fruk, Enhanced Photocatalytic Activity of Au/TiO2 Nanocomposite Prepared Using Bifunctional Bridging Linker, Adv. Funct. Mater 2014, 24(7), 1028.

  10. D. M. Bauer, A. Rogge, L. Stolzer, C. Barner-Kowollik, Lj. Fruk, Light Induced DNA-protein conjugation, Chem. Commun. 2013, 49, 8626.

  11. . Ahmed, Lj. Fruk, The Power of Light: Photosensitive Tools for Chemical Biology, MolBiosyst 2013, 9(4), 565.

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Collaborators

Dr. Tijmen Euser, Cavendish lab

Prof. Christopher Barner-Kowollik, Queensland University of Technology, Brisbane  (Photo triggered click chemistry) 

©2020 by Fruk lab